标题：Compartmentalized Multilayer Hydrogel Formation Using a Stimulus-Responsive Self-Assembling Polysaccharide作者：Xiong, Yuan; Yan, Kun; Bentley, William E.; Deng, Hongbing; Du, Yumin;Payne, Gregory F.; Shi, Xiao-Wen

来源出版物：ACS APPLIED MATERIALS & INTERFACES 卷：6 期：4 页：2955-2964 DOI：10.1021/am405544r 出版年：FEB 26 2014

摘要：Polymeric systems that self-assemble through strong noncovalent bonds form structures that are highly dependent on the spatiotemporal sequence of cues that trigger self-assembly. Here, we prepared capsules with a semipermeable alginate-chitosan polyelectrolyte membrane that encapsulates a solution of the pH-responsive self-assembling aminopolysaccharide chitosan. Immersion of these capsules in a basic solution triggers gelation of the capsule contents, and the details of the gel-inducing treatment dramatically affect the final structure of the gelled compartment. Specifically, we show that the sequential transfer of the capsules between the base and water can generate multilayer hydrogel structures, with the thickness of each layer being controlled by the base concentration and immersion times. We further demonstrate that these multilayer hydrogels can serve as templates for the synthesis of iron oxide particles with a complex internal structure (i.e., with a multilayer internal structure). This work demonstrates the ability to enlist the stimulus-responsive self-assembling properties of biological polymers to create materials with complex structures.

入藏号：WOS:000332144600098

文献类型：Article

语种：English

作者关键词：chitosan, external stimuli, interrupted gelation, multilayer, self-assembly

扩展关键词：SILK IONOMER MICROCAPSULES; BIOMEDICAL APPLICATIONS; MEMBRANE HYDROGELS; CHITOSAN; CAPSULES; ALGINATE; PERMEABILITY; ORGANIZATION; PARTICLES; VERSATILE

通讯作者地址：Payne, Gregory F.; Wuhan Univ, Sch Resource & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

电子邮件地址：gpayne@umd.edu; shixwwhu@163.com

地址：

[Xiong, Yuan; Yan, Kun; Deng, Hongbing; Du, Yumin; Payne, Gregory F.; Shi, Xiao-Wen]Wuhan Univ, Sch Resource & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

[Bentley, William E.; Payne, Gregory F.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.

[Bentley, William E.; Payne, Gregory F.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.

研究方向：Science & Technology - Other Topics; Materials Science

ISSN：1944-8244