标题：Electrical signals guided entrapment and controlled release of antibiotics on titanium surface作者：Shi, Xiaowen; Wu, Huiping; Li, Yuanyuan; Wei, Xiaoquan; Du, Yumin

来源出版物：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 卷：101A 期：5 页：1373-1378 DOI：10.1002/jbm.a.34432 出版年：MAY 2013

摘要：Electrical signals are used to trigger the entrapment and release of antibiotics on the surface of titanium plate. The entrapment of antibiotics relies on the electrochemically induced pH gradient generated at the titanium surface that allows the gelation of an aminopolysaccharide chitosan and codeposition of vancomycin, a common antibiotic, within chitosan gel. The release of vancomycin is controlled by an anodic signal imposed to the titanium plate that causes a pH decrease and erosion of chitosan gel. We show that the on demand entrapment and release of vancomycin at the surface of titanium plate is fundamentally altered and controlled by voltage. We expect that this rapid, mild and facile electrochemical process for antibiotics loading and release will find applications in controlled drug release from titanium implants.

入藏号：WOS:000316815700017

文献类型：Article

语种：English

作者关键词：chitosan, hydrogel, electrodeposition, titanium, controlled drug release

扩展关键词：CONTROLLED DRUG-RELEASE; POLYMER-HYDROGEL; COATED TITANIUM; CHITOSAN; ALLOY; DELIVERY; VANCOMYCIN; DEPOSITION; MICROCHIP; ADHESION

通讯作者地址：Shi Xiaowen;Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

电子邮件地址：shixwwhu@163.com

地址：

[Shi, Xiaowen; Wu, Huiping; Wei, Xiaoquan; Du, Yumin] WuhanUniv, Dept Environm Sci, Sch Resource & EnvironmSci,HubeiBiomass Resource Chem & Environm Biotechnol,Wuhan 430079, Peoples RChina.

[Li, Yuanyuan] Huazhong Univ Sci & Technol, Inst Environm Med, Key Lab Environm* & Hlth, Tongji Med Coll,Minist Educ,Sch Publ Hlth,Wuhan430030, Peoples RChina.

研究方向：Engineering; Materials Science

ISSN：1549-3296